Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases
نویسندگان
چکیده
منابع مشابه
Mucosal-Associated Invariant T Cells in Inflammatory Bowel Diseases: Bystanders, Defenders, or Offenders?
The quest for new therapeutics and better follow-up of patients with inflammatory bowel diseases (IBD) requires the clearest possible picture of the immunological mechanisms underlying these complex pathologies. We identified recently a potential new player in this destructive game, a non-conventional T cell subset called Mucosal-Associated Invariant T (MAIT) cells. These cells were initially i...
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The recently described Mucosal Associated Invariant T (MAIT) cells mediate specific recognition of bacterial and fungal vitamin B2 metabolites. As innate T cells, they possess broad effector responses, including IFN- including Iproduction, that are comparable to conventional T cell responses. Immunodeficiencies associated with systemic Th17 deficiency may also be compounded by defects in MAIT i...
متن کاملMucosal-associated invariant T cells in clinical diseases.
UNLABELLED Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial infection via vitamin metabolites. The discovery of MAIT cells in the past two decades and the recent discovery of MR1 ligands has opened a new field and potential area for cellular immunotherapy using these unique cells. Their evolutionary conservation in mammals underscore their biological ...
متن کاملHuman Leptin Hormone Affects TNF-α Production in Mucosal-associated Invariant T Cells
Background and Aims: Mucosal-associated invariant T (MAIT) cells are striking lymphocyte population in the blood and their importance in immune responses is growing fast. The current study was conducted to evaluate leptin hormone effects on MAIT cell functions. Materials and Methods: Five healthy male donors in ages of 22-30 years were selected and peripheral blood mononuclear cells (PBMCs) ...
متن کاملmucosal-associated invariant T cells
© 2008 Huang et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1201-1211 www.jem.org/cgi/doi/ 1201 10.1084/jem.20072579 Mucosal-associated invariant T cells (MAITs) are a unique “ innate ” T cell population that expresses an invariant mV 19 TCR in mice and the homologous hV 7.2 in humans ( 1 ). With the exception of preferential localization in the intestine, MAIT cell...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2014
ISSN: 0009-9104
DOI: 10.1111/cei.12277